Papers tagged: cancer

REMAP, a lineage-tracing mouse model coupling inducible CRISPR recording with the MMTV-PyMT model of HR+ breast cancer, reveals heritable clonal programs governing metastasis and response to combined radiation and anti-PD1 immunotherapy.

Using FLARE, a hierarchical dynamic lineage tracing method, to track AML cell lines through Cytarabine exposure, revealing distinct cellular lineages predisposed to persistence and resistance via upregulation of cell adhesion and motility pathways.

Using macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder, to trace metastatic pancreatic cancer and reveal that metastatic potential peaks in rare, late-hybrid EMT states.